Selected Publications (1990-present):
____ *Denotes a Review Article

• Xiao, M, Xu, L, Laezza, F, Yamada, K, Feng, S, and Ornitz, DM, (2007). Impaired hippocampal synaptic transmission and plasticity in mice lacking fibroblast growth factor 14. Mol Cell Neurosci, 34, 366-377.
  
• Hung, I.H., Yu, K., Lavine, K.J., and Ornitz D.M., (2007). FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod. Dev Biol, 307(2), 300-313.
  
• Hughes, I., Saito, M., Schlessinger, P. H., and Ornitz, D. M. (2007) Otopetrin1: a novel purinergic nucleotide-gated regulator of intracellular calcium, Proc Natl Acad Sci U S A, 104(29), 12023-12028..     
• White, A. C., Lavine, K.J. and Ornitz, D.M. (2007) FGF9 and SHH Regulate Mesenchymal Vegfa Expression and Development of the Pulmonary Capillary Network, Development, 134(20): 3743-3752.
  
• Saarimaki-Vire, J., Peltopuro, P., Lahti, L., Naserke, T., Blak, A.A., Vogt Weisenhorn, D.M., Yu, K., Ornitz, D.M., Wurst, W., and Partanen, J. (2007) Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain. J Neurosci, 27(32): 8581-8592.
  
• Laezza, F., Gerber, B.R., Lou, J., Kozel, M.A., Hartman, H., Craig, A.M., Ornitz, D.M. and Nerbonne, J.M. (2007). The Fgf14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability. J. Neurosci., in press.
  
• Lavine, K. J., White, A. C., Park, C., Smith, C. S., Choi, K., Long, F., Hui, C. C., and Ornitz, D. M. (2006). Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev, 20, 1651-1666.
• Zhang, X., Stappenbeck, T. S., White, A. C., Lavine, K. J., Gordon, J. I., and Ornitz, D. M. (2006). Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development. Development 133, 173-180.
• McDowell, L. M., Frazier, B. A., Studelska, D. R., Giljum, K., Chen, J., Liu, J., Yu, K., Ornitz, D. M., and Zhang, L. (2005). Inhibition or activation of apert syndrome Fgfr2 (S252W) signaling by pecific glycosaminoglycans. J Biol Chem. In press
• Lou, J. Y., Laezza, F., Gerber, B. R., Xiao, M., Yamada, K. A., Hartmann, H., Craig, A. M., Nerbonne, J. M., and Ornitz, D. M. (2005) Fibroblast Growth Factor 14 is an Intracellular Modulator of Voltage-Gated Sodium Channels. J Physiol 569, 179-193.
• Yu, X., Ibrahimi, O. A., Goetz, R., Zhang, F., Davis, S. I., Garringer, H. J., Linhardt, R. J., Ornitz, D. M., Mohammadi, M., and White, K. E. (2005) Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23.Endocrinology 146, 4647-4656.
• Wang, Y., Xiao, R., Yang, F., Karim, B. O., Iacovelli, A. J., Cai, J., Lerner, C. P., Richtsmeier, J. T., Leszl, J. M., Hill, C. A., Yu, K., Ornitz, D. M., Elisseeff, J., Huso, D. L., and Jabs, E. W. (2005), Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse, Development 132(15), 3537-3548
• Garcia, C. M., Yu, K., Zhao, H., Ashery-Padan, R., Ornitz, D. M., Robinson, M. L., and Beebe, D. C. (2005), Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation, Dev Dyn233, 516-527.
• White, K. E., Cabral, J. M., Davis, S. I., Fishburn, T., Evans, W. E., Ichikawa, S., Fields, J., Yu, X., Shaw, N. J., McLellan, N. J., McKeown, C., Fitzpatrick, D., Yu, K., Ornitz, D. M., and Econs, M. J. (2004), Mutations that Cause Osteoglophonic Dysplasia Define Novel Roles for FGFR1 in Bone Elongation, Am J Hum Genet 76, 361-367.
• Hu, H., Hilton, M. J., Tu, X., Yu, K., Ornitz, D. M., and Long, F. (2005), Sequential roles of Hedgehog and Wnt signaling in osteoblast development, Development 132, 49-60
• Xiao, L., Naganawa, T., Obugunde, E., Gronowicz, G., Ornitz, D. M., Coffin, J. D., and Hurley, M. M. (2004), Stat1 controls post natal bone formation by regulating FGF signaling in osteoblasts, J Biol Chem
• *Itoh, N., and Ornitz, D. M. (2004), Evolution of the Fgf and Fgfr gene families, Trends Genet. 20, 563-569.
• Valverde-Franco, G., Liu, H., Davidson, D., Chai, S., Valderrama-Carvajal, H., Goltzman, D., Ornitz, D. M., and Henderson, J. E. (2004), Defective bone mineralization and osteopenia in young adult FGFR3-/- mice, Hum Mol Genet 13, 271-284
• Umemori, H., Linhoff, M. W., Ornitz, D. M., and Sanes, J. R. (2004), FGF22 and Its Close Relatives Are Presynaptic Organizing Molecules in the Mammalian Brain, Cell 118, 257-270
• Schmahl, J., Kim, Y., Colvin, J. S., Ornitz, D. M., and Capel, B. (2004), Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination, Development
• Pirvola, U., Zhang, X., Mantela, J., Ornitz, D. M., and Ylikoski, J. (2004), Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions, Dev Biol 273, 350-360
• Long, H., Sabatier, C., Le, M., Plump, A., Yuan, W., Ornitz, D. M., Tamada, A., Murakami, F., Goodman, C. S., and Tessier-Lavigne, M. (2004), Conserved roles for slit and robo proteins in midline commissural axon guidance, Neuron 42, 213-223
• Ignatova, E. G., Thalmann, I., Xu, B., Ornitz, D. M., and Thalmann, R. (2004), Molecular mechanisms underlying ectopic otoconia-like particles in the endolymphatic sac of embryonic mice, Hearing Research 194, 65-72
• Hughes, I., Blasiole, B., Huss, D., Warchol, M. E., Rathe, N. P., Hurle, B., Ignatova, E., Dickman, J. D., Thalmann, R., Levenson, R., and Ornitz, D. M. (2004), Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio, Dev. Biol, 15;276(2):391-402
• Bialek, P., Kern, B., Yang, X., Schrock, M., Sosic, D., Hong, N., Wu, H., Yu, K., Ornitz, D. M., Olson, E. N., Justice, M. J., and Karsenty, G. (2004), A twist code determines the onset of osteoblast differentiation, Dev Cell 6, 423-435
• Amizuka, N., Davidson, D., Liu, H., Valverde-Franco, G., Chai, S., Maeda, T., Ozawa, H., Hammond, V., Ornitz, D. M., Goltzman, D., and Henderson, J. E. (2004), Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development, Bone 34, 13-25
• Yuan, W., Rao, Y., Babiuk, R. P., Greer, J. J., Wu, J. Y., and Ornitz, D. M. (2003), A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3, Proc Natl Acad Sci U S A 100, 5217-5222
• Yu, K., Xu, J., Liu, Z., Sosic, D., Shao, J., Olson, E. N., Towler, D. A., and Ornitz, D. M. (2003), Conditional Inactivation of FGF Receptor 2 Reveals an Essential role for FGF Signaling in the Regulation of Osteoblast Function and Bone Growth, Development 130, 3063-3074
• Sosic, D., Richardson, J.A., Yu, K., Ornitz, D.M., Olson, E.N. (2003). Twist Regulates Cytokine Gene Expressionthrough a Negative Feedback Loop that Represses NF-kB Activity. Cell. 112:169-180.
• Olsen, S. K., Garbi, M., Zampieri, N., Eliseenkova, A. V., Ornitz, D. M., Goldfarb, M., and Mohammadi, M. (2003), Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs., J Biol Chem 278, 34226-34236
• Pauley, S., Wright, T. J., Pirvola, U., Ornitz, D., Beisel, K., and Fritzsch, B. (2003), Expression and function of FGF10 in mammalian inner ear development, Dev Dyn 227, 203-215
• Pringle, N. P., Yu, W. P., Howell, M., Colvin, J. S., Ornitz, D. M., and Richardson, W. D. (2003), Fgfr3 expression by astrocytes and their precursors: evidence that astrocytes and oligodendrocytes originate in distinct neuroepithelial domains, Development 130, 93-102
• *Ornitz, D. M. (2003) Evolution of Fibroblast Growth Factors, in Encyclopedia of the Human Genome, pp. in press, Nature Publishing Group, New YorkHurle, B., Ignatova, E., Massironi, S.M., Mashimo, T., Rios, X., Thalmann, I., Thalmann, R., Ornitz, D.M. (2003). Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1. Hum. Mol. Gen. 12:777-789.
• Oh, L.Y.S., Denninger, A., Colvin., J.S., Vyas, Aditee, Tole, S., Ornitz, D.M., Bansal, R. (2003). Fibroblast Growth Factor Receptor 3 Signaling Regulates the Onset of Oligodendrocyte Terminal Differentiation. J. Neurosci. 23:883-894.
• Liu, Z., Xu, J., Colvin, J.S., Ornitz, D.M. (2002). Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. Gene Dev. 16:859 –869.
• *Ornitz, D.M., Marie, P.J. (2002). FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev., 16:1446 –1465.
• Wang, Q., Bardgett, M.E., Wong, M., Wozniak, D.F., Lou, J., McNeil, B.D., Chen, C., Nardi, A., Reid, D.C., Yamada, K., Ornitz, D.M. (2002). Ataxia and Paroxysmal Dyskinesia in Mice Lacking Axonally Transported FGF14. Neuron. 35:25-38
• Minina, E., Kreschel, C., Naski, M.C., Ornitz, D.M., Vortkamp, A. (2002). Interaction of FGF, Ihh/Pthlh, and BMP Signaling Integrates Chondrocyte Proliferation and Hypertrophic Differentiation. Devel. Cell. 3:1-20.
• Willis, D.M., Loewy, A.P., Charlton-Kachigian, N., Shao, J.S., Ornitz, D.M., Towler, D.A. (2002). Regulation of Osteocalcin Gene Expression by a Novel Ku Antigen
  Transcription Factor Complex. J. Biol. Chem. 277:37280-37291.
• Zhao, S., Hung, F.C., Colvin, J.S., White, A., Dai, W., Lovicu, F.J., Ornitz, D.M., Overbeek, P.A. (2001) Patterning the optic neuroepithelium by FGF signaling and Ras activation. Development. 128:5051-5060.
• Ibrahimi, O.A., A.V. Eliseenkova, et al. (2001). Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome. Proc. Natl. Acad. Sci. Early Edition U.S.A. In press.
• Colvin, J.S., A.C. White, et al. (2001). Lung hypoplasia and neonatal dath in Fgf9-null mice identify this gene as an essential regulator of lung medsenchyme. Development. 128:2095-2106.
• Hurle, B., Lane, K., Kenney, J., Tarantino, L., Bucan, M., Brownstein, B., Ornitz, D. M. (2001). Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development. Genomics 77: 189-199.
• Wang Q., Green, R., Zhao, G., Orntiz, D. M. (2001). Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains. Development 128: 3867-3876.
• Colvin, J. S., White, A., Pratt, S. J. and Ornitz, D. M. (2001). Lung hypoplasia and neonatal death in mice lacking fibroblast growth factor 9 identify Fgf9 as an essential regulator of lung mesenchyme. Development, 128: 2095-2106.
• Yu, K., and Ornitz, D. M. (2001). Uncoupling FGF receptor 2 activation and ligand binding specificity: Multiple paths to Apert syndrome-like phenotypes. Proc. Natl. Acad. Sci., U S A, 98, 3641-3643.
• Ornitz, D. M. and Itoh, N. (2001). Fibroblast growth factors. Genome Biology, 3005.1-3005.12. Colvin, J. S., Green, R. P., Schmahl, J., Capel, B. and Ornitz, D. M. (2001). Male-to-female sex reversal in mice lacking fibroblast growth factor 9. Cell 104:875-889.
• Yu, K., Herr, A. B., Waksman, G. and Ornitz, D. M. (2000). Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome. Proc. Natl. Acad. Sci. USA 97: 14536-14541.
• Xu, J. S., Liu, Z. H. and Ornitz, D. M. (2000). Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. Development 127: 1833-1843.
• Wang, Q., McEwen D.G., et al. (2000). Subcellular and developmental expression of alternatively spliced forms of fibrobroblast growth factor 14. Mech. Devel. 90: 283-287.
• Tarantino, L. M., Feiner, L., Alireza Alavizadeh, A., T., W., Hurle, B., Ornitz, D., Rowe, L. B., Webber, A. L., Raper, J., Lengeling, A. and Bucan, M. (2000). A high-resolution radiation hybrid map of the proximal portion of mouse Chromosome 5. Genomics 66: 55-64.
• Henderson, J. E., Naski, M. C., Aarts, M. M., Wang, D., Cheng, L., Goltzman, D. and Ornitz, D. M. (2000). Expression of FGFR3 with the G380R achondroplasia mutation inhibits proliferation and maturation of CFK2 chondrocytic cells. J. Bone Miner. Res. 15: 155-165.
• Ornitz, D.M. (2000). FGFs, heparan sulfate and FGFRs: complex interactions essential for development. Bioessays 22:108-112.
• Colvin, J. S., B. Feldman, et al. (1999). Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene. Dev. Dy 216, 72-88.
• Yuan, W., L. Zhou, et al. (1999). The mouse SLIT family: Secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Dev. Biol. 212, 290-306.
• Thalmann, R., R. Echols, et al. (1999). Unresolved issues of biology and pathology of otoconia. in Equilibrium in research and equilibriometry and modern treatment. C.-F. Clausen. Amsterdam, Elsevier. Claussen, C-F. Chellaiah, A., Yuan, W., et al. (1999). Mapping Ligand Binding Domains in Chimeric Fibroblast Growth Receptor Modules. J. Biol. Chem. 274: 34785-34794.
• McEwen, D.G., Green, R.P., et al. (1999). Fibroblast Growth Factor Receptor 3 Gene Transcription Is Suppressed by Cyclic Adenosine 3', 5'-Monophosphate. J. Biol. Chem. 274: 30934-30942.
• Wang, Y., I. Thalmann, et al. (1999). Mapping the mouse Otoconin-90 (Oc90) gene to chromosome 15. Genomics 58: 214-215.
• Li, H. S., J. H. Chen, et al. (1999). Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Cell 96(6): 807-818.
• Xu, J., A. Lawshe, et al. (1999). Genomic structure, mapping, activity and expression of fibroblast growth factor 17. Mech. Devel. 83: 165-178.
• Ying, H. C., B. Hurle, et al. (1999). High resolution mapping of tlt, a mouse mutant lacking otoconia. Mam. Genome 10: 544-548.
• Daphna-Iken, D., D. B. Shankar, et al. (1998). MMTV-FGF8 transgenic mice develop mammary and salivary gland neoplasia and ovarian stromal hyperplasia. Oncogene 17: 2711-2717.
• Wang, Y., P. E. Kowalski, et al. (1998). Otoconin-90, the mammalian otoconial matrix protein contains two domains of homology to secretory phospholipase A2. Proc. Natl. Acad. Sci., USA 95: 15345-15350.
• Greene, J. M., L. Y. Li, et al. (1998). Identification and characterization of a novel member of the fibroblast growth factor family. Eur. J. Neurosci. 10(5): 1911-1925.
• Kato, M., H. M. Wang, et al. (1998). Physiological Degradation Converts the Soluble Syndecan-1 Ectodomain From an Inhibitor to a Potent Activator of Fgf-2. Nature Medicine 4(6): 691-697.
• Lin, H.-Y., J. Xu, et al. (1998). Identification of the cytoplasmic regions of fibroblast growth factor (FGF) receptor 1 which play important roles in the induction of neurite outgrowth in PC12 cells by FGF-1. Mol. Cell. Biol. 18(7): 3762-3770.
• McEwen, D. G. and D. M. Ornitz (1998). Regulation of the fibroblast growth factor receptor 3 promoter and intron I enhancer by Sp1 family transcription factors. J. Biol. Chem. 273: 5349-5357.
• Naski, M. C., J. S. Colvin, et al. (1998). Repression of hedgehog signaling and BMP4 expression by fibroblast growth factor receptor 3 in growth plate cartilage of transgenic mice. Development 125: 4977-4988.
• Naski, M. C. and D. M. Ornitz (1998). FGF signaling in skeletal development. Front. Biosci. 3: D781-94.
• Ornitz, D. M., B. A. Bohne, et al. (1998). Otoconial agenesis in titled mutant mice. Hearing Res. 122: 60-70.
• Xu, X., M. Weinstein, et al. (1998). Fibroblast growth factor receptor 2 (FGFR2)-mediated regulation loop between FGF8 and FGF10 is essential for limb induction. Development 125: 753-765.
• Blunt, A. G., A. Lawshe, et al. (1997). Overlapping expression and redundant activation of mesenchymal fibroblast growth factor (FGF) receptors by alternatively spliced FGF-8 ligands. J. Biol. Chem. 272(6): 3733-3738.
• Herr, A. B., D. M., et al. (1997). Heparin-induced self-association of fibroblast growth factor-2. Evidence for two oligomerization processes. J Biol Chem 272(26): 16382-16389.
• McEwen, D. G. and D. M. Ornitz (1997). Determination of fibroblast growth factor receptor expression in mouse, rat and human samples using a single primer pair. Biotechniques 22(6): 1068-1070.
• Miao, H.-Q., D. M. Ornitz, et al. (1997). Modulation of fibroblast growth factor-2 receptor binding, dimerization, signaling, and angiogenic activity by a synthetic heparin-mimicking polyanionic compound. J. Clin. Invest. 99: 1565-1575.
• Ornitz, D. M. and G. Waksman (1997). Fibroblast growth factor receptors. Growth factors and wound healing: Basic science and potential clinical applications. T. R. Ziegler, G. F. Pierce and D. N. Herndon. New York, Springer-verlag: 151-174.
  Osterhout, D. J., S. Ebner, et al. (1997). Transplanted oligodendrocyte progenitor cells expressing a dominant-negative FGF receptor transgene fail to migrate in vivo. J. Neurosci. 17(23): 9122-9132.
• Colvin, J. S., B. A. Bohne, et al. (1996). Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat. Genet. 12: 390-397.
• Lin, H. Y., J. S. Xu, et al. (1996). The fibroblast growth factor receptor-1 is necessary for the induction of neurite outgrowth in PC12 cells by aFGF. J. Neuroscience 16(15): 4579-4587.
• Naski, M. C., Q. Wang, et al. (1996). Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nat. Genet. 13: 233-237.
• Ornitz, D. M., J. Xu, et al. (1996). Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271(25): 15292-15297.
• Santos-Ocampo, S., J. S. Colvin, et al. (1996). Expression and biological activity of mouse fibroblast growth factor-9. J. Biol. Chem. 271: 1726-1731.
• Venkataraman, G., V. Sasisekharan, et al. (1996). Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation. Proc. Natl. Acad. Sci. U.S.A. 93: 845-850.
• Benvenisty, N. and D. M. Ornitz (1995). BK1: An FGF-responsive central nervous system-derived cell line. Growth Factors 12: 49-55.
• MacArthur, C. A., A. Lawshe, et al. (1995). FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development. Development 121: 3603-3613.
• Mathieu, M., E. Chatelain, et al. (1995). Receptor binding and mitogenic properties of mouse fibroblast growth factor 3 (FGF3); modulation of response by heparin. J. Biol. Chem. 270(41): 24197-24203.
• Ornitz, D. M., A. B. Herr, et al. (1995). FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides. Science 268: 432-436.
  Westman, J., M. Nilsson, et al. (1995). Synthesis and fibroblast growth factor binding of oligosaccharides related to heparin and heparan sulphate. J. Carbohydrate Chem. 14(1): 95-113.
• Chellaiah, A. T., D. G. McEwen, et al. (1994). Fibroblast growth factor receptor (FGFR) 3: Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1. J. Biol. Chem. 269(15): 11620-11627.
• Deng, C. X., A. Wynshaw-Boris, et al. (1994). Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev. 8: 3045-3057.
• Shen, M. M., R. C. Skoda, et al. (1994). Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies. EMBO J. 13(6): 1375-1385.
• Peters, K., D. M. Ornitz, et al. (1993). Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis. Dev. Biol. 155: 423-430.
• Benvenisty, N., D. M. Ornitz, et al. (1992). Brain tumors and lymphomas in transgenic mice that carry HTLV-I LTR/c-myc and Ig/tax genes. Oncogene. 7: 2399-2405.
• Ornitz, D. M., R. D. Cardiff, et al. (1992). Int-2, an autocrine and/or ultra-short-range effector in transgenic mammary tissue transplants. J. Natl. Canc. Inst. 84(11): 887-892.
• Ornitz, D. M. and P. Leder (1992). Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3. J. Biol. Chem. 267: 16305-16311.
• Ornitz, D. M., R. Skoda, et al. (1992). Regulating Gene expression in mammalian cell culture and transgenic mice with yeast GAL4/UAS control elements. NATO ASI series. Oncogene and transgenic correlates of cancer risk assessments. C. Zervos. in press.
• Ornitz, D. M., A. Yayon, et al. (1992). Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells. Mol. Cell. Biol. 12: 240-247.
• Ornitz, D. M., R. W. Moreadith, et al. (1991). Binary system for regulating transgene expression in mice: Targeting int-2 gene expression with yeast GAL4/UAS control elements. Proc. Natl. Acad. Sci. USA 88: 698-702.
• Yayon, A., M. Klagsbrun, et al. (1991). Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 64: 841-848.