More information about David Ornitz and his laboratory: bio sketch,
research interests, selected publications and laboratory resources.
Selected laboratory protocols, such as: alkaline
plasmid prep, BrdU immunohistochemistry, LacZ embryo staining, RNase
protection assay and many others.
Information and graphics concerncing fibroblast growth factor research,
such as: FGF family tree, FGFR mutations, FGF specificity data and
more.
Information
on vestibular system projects; QuickTime movie of a mouse swim test
in the Ornitz lab. The goal of this work is to identify the genes
required for otoconia biosynthesis and the function of the gravity
receptor.
Neurobiology and the function of Intracellular FGFs(iFGFs): Intracellular Fibroblast Growth Factors (iFGFs) are important regulators of the activity of many different neurons in the brain and throughout the body
Many of the human craniosynostosis and chondrodysplasia syndromes are caused by missense mutations inthe genes encoding FGF receptors (FGFRs) 1, 2 and 3.
Fibroblast Growth Factors (FGFs) have been proposed as important regulators of growth and function of the heart and as important angiogenic factors.
Mice lacking FGF9 have defects in lung branching and lung mesoderm
proliferation. These mice also have a male to female sex reversal
secondary to decreased growth of testicular mesenchyme and failure
of normal Sertoli and Lydig cell development.
Apert Syndrome manifests itself in premature ossification and fusion
of the sutures between the developing flat bones of the skull; osseous
fusion of digits and phalangeal joints; soft-tissue syndactyly in
hands and feet; and in central nervous system malformations and
mental retardation.
Links to other programs within the School of Medicine, and to other
areas of interest.
Laboratory
Members and Contact Information
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