Selected Recent Publications

Li, H., Guo, W., and Nerbonne, J.M. KChIP2 modulates cell surface expression of Kv1.5-encoded K⁺ channels, submitted (Journal of Biological Chemistry).

Brunet, S., Aimond, F., Li, H., Guo, W., Eldstrom, J., Fedida, D.A., Yamada, K.A., and Nerbonne, J.M. Heterogeneous expression of repolarizing voltage-gated K⁺ currents in adult mouse ventricles, submitted (Journal of Physiology, London).

Dong, H.W., Shao Z.W., Nerbonne, J.M., and Burkhalter, A. Frequency-dependent balance of synaptic excitation and inhibition in interareal forward and feedback circuits in mouse visual cortex. Journal of Comparative Neurology, in press (2004).

Kodirov, S., Brunner, M., Busconi, L., Nerbonne, J.M., Buckett, P., Mitchell, G., and Koren, G. Attenuation of I_K,slow1 and I_K,slow2 in Kv1 DN mice prolongs the APD and QT intervals but does not prevent spontaneous or inducible arrhythmias. American Journal of Physiology 286: H368-H374 (2004).

Li, H., Guo, W., Yamada, K.A., and Nerbonne, J.M. Selective elimination of one component of delayed rectification, I_K,slow1, in mouse ventricular myocytes expressing a dominant negative Kv1.5 -subunit. American Journal of Physiology 286: H319-H328 (2004).

Pal, S., Hartnett, K.A., Nerbonne, J.M., Levitan, E.S., and Aizenman, E. Mediation of neuronal apoptosis by Kv2.1-encoded potassium channels in rat cortical neurons. Journal of Neuroscience 23: 4798-4802 (2003).

Rosati, B., Grau, F., Rodriguez, S., Li, H., Nerbonne, J.M., and McKinnon, D. Co-ordinate patterns of KChIP2 mRNA, protein and transient outward current expression throughout canine ventricle. Journal of Physiology, London 548: 815-822 (2003).

Finck, B.N., Xianlin H., Courtois, M., Aimond, F., Nerbonne, J.M., Kovacs, A., Gross, R.W., and Kelly, D.P. A critical role for PPAR-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation of phenotype by dietary fat content. Proceedings of the National Academy of Sciences, USA 100: 1226-1231 (2003).

Le Bouter, S., Demolombe, S., Chambellan, A., Bellocq, C., Toumaniantz, G., Lande, G., Siavoshian, S., Baró, I., Pond, A. L., Nerbonne, J.M., Léger, J.J., Escande, D., and Charpentier, F. MicroArray analysis reveals complex remodeling of cardiac ion channel expression with altered thyroid status: relation to cellular and integrated electrophysiology. Circulation Research 92: 234-242 (2003).

Zhou, J., Kodirov, S, Murata, M., Buckett, P.D., Nerbonne, J.M., and Koren, G. Regional upregulation of Kv2.1-encoded current, I_K,slow2, in Kv1 DN mice is abolished by crossbreeding with Kv2 DN mice. American Journal of Physiology 284: H491-H500 (2003).

Malin, S., and Nerbonne, J.M. Delayed rectifier K⁺ currents, I_K, are encoded by Kv2 a subunits and regulate tonic firing in mammalian sympathetic neurons. Journal of Neuroscience 22: 10094-10105 (2002).

Guo, W., Malin, S.A., Johns, D.C., Jeromin, A., and Nerbonne, J.M. Modulation of Kv4-encoded K⁺ currents in the mammalian myocardium by neuronal calcium sensor-1. Journal of Biological Chemistry 277: 26436-26443 (2002).

Nerbonne, J.M., and Guo, W. Heterogeneous expression of voltage-gated K⁺ channels in the heart: roles in normal excitation and arrhythmias. Journal of Cardiovascular Electrophysiology 13: 406-409 (2002).

Nerbonne, J.M., Nichols, C.G., Schwarz, T.L., and Escande, D. Genetic manipulation of cardiac K⁺ channel function: What have we learned and where do we go from here? Circulation Research 89: 944-956 (2001).

Pond, A.L., and Nerbonne, J.M. ERG proteins and functional I_Kr channels in rat, mouse and human heart. Trends in Cardiovascular Medicine 11: 286-294 (2001).

Li, H., Guo, W., Hood, R., Benedict, A., Xu, H., and Nerbonne, J.M. Heterogeneity in the functional expression of a GFP-tagged Kv1.5 -subunit in mouse ventricles. American Journal of Physiology 281: H1955-H1967 (2001).

Malin, S.A., and Nerbonne, J.M. Molecular Heterogeneity of the Voltage-Gated Fast Transient Outward K⁺ Current, I_Af, in Mammalian Neurons. Journal of Neuroscience 21: 8004-8014 (2001).

Brunner, M., Guo, W., Mitchell, G.F., Buckett, P.D., Nerbonne, J.M., and Koren, G. Characterization of mice with a combined suppression of I_to and I_K,slow. American Journal of Physiology 281: H1201-H1209 (2001).

London, B., Guo, W., Pan, X.H., Lee, J.S., Shusterman, V., Logothetis, D.A., Nerbonne, J.M., and Hill, J.A. Targeted replacement of Kv1.5 in the mouse leads to loss of the 4 amino pyridine-sensitive component of I_K,slow and resistance to drug-induced QT prolongation. Circulation Research, 88: 940-946 (2001).

Feng, G., Hood, R., Bernstein, M., Keller-Peck, C., Nguyen, Q., Wallace, M., Nerbonne, J.M., Lichtman, J.W., and Sanes, J.R. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 28: 41-51 (2000).

Bou-Abboud, E., Li, H., and Nerbonne, J.M. Molecular diversity of the repolarizing voltage-gated K⁺ currents in mouse atrial myocytes. Journal of Physiology, London 529: 345-358 (2000).

Guo, W., Li, H., London, B., and Nerbonne, J.M. Functional consequences of elimination of I_to,f and I_to,s: early afterdepolarizations, atrioventricular block and ventricular arrhythmias in mice lacking Kv1.4 and expressing a dominant-negative Kv4 -subunit. Circulation Research, 87: 73-79 (2000).

Malin, S., and Nerbonne, J.M. Elimination of the Fast Transient in Superior Cervical Ganglion Neurons with Expression of KV4.2W362F: Molecular dissection of I_A. Journal of Neuroscience, 20: 5191-5199 (2000).

Emmi, A., Wenzel, J., Schwartzkroin, P.A., Tagliatela, M., Castaldo, L., Bianchi, L., Robertson, G.A., Nerbonne, J.M., and Janigro, D. Do Glia Have Heart? Expression and Functional Role for Ether-A-Go-Go Currents in Hippocampal Astrocytes. Journal of Neuroscience, 20: 3915 - 3925 (2000).

Gussak, I., Chaitman, B.R., Kopecky, S.L., and Nerbonne, J.M. Rapid ventricular repolarization in rodents: Electrocardiographic manifestations, molecular mechanisms, and clinical insights. Journal of Electrocardiology, 33: 159-170 (2000).

Pond, A.L., Scheve, B.K., Benedict, A.T., Petrecca, K., Van Wagoner, D.R., Shrier, A., and Nerbonne, J.M. Expression of distinct ERG proteins in rat, mouse and human heart: relation to functional I _Kr channels. Journal of Biological Chemistry, 275: 5997-6006 (2000).

Nerbonne, J.M. Molecular basis of functional voltage-gated K⁺ channel diversity in the mammalian myocardium. Journal of Physiology, London 525: 285-298 (2000).

Guo, W., Xu, H., London, B., and Nerbonne, J.M. Molecular basis of transient outward K⁺ current diversity in mouse ventricular myocytes. Journal of Physiology, London, 521: 587-599 (1999).

Xu, H., Barry, D.M., Li, H., Brunet, S., Guo, W., and Nerbonne, J.M. Attenuation of the slow component of delayed rectification, action potential prolongation and triggered activity in mice expressing a dominant-negative Kv2 -subunit. Circulation Research, 85: 623-633 (1999).

Van Wagoner, D.R., Pond, A.L., Lamorgese, M., Rossie, S.S., and Nerbonne, J.M. Atrial L-Type Ca²⁺ Currents and Human Atrial Fibrillation. Circulation Research, 85: 428-436 (1999).

Xu, H., Li, H., and Nerbonne, J.M. Elimination of the transient outward current and action potential prolongation in mouse atrial myocytes expressing a dominant negative Kv4 -subunit, Journal of Physiology, London 519: 11-21 (1999).

Bou-Abboud, E., and Nerbonne, J.M. Molecular correlates of the Ca⁺⁺-independent, depolarization activated K⁺ channels in rat atrial myocytes. Journal of Physiology, London 517: 407-420 (1999).

Xu, H., Guo, W., and Nerbonne, J.M. Four kinetically-distinct depolarization-activated K⁺ currents in adult mouse ventricular myocytes. Journal of General Physiology 113: 661-678 (1999).

Brahmajothi, M.V., Campbell, D.L., Rasmusson, R.L., Morales, M.J., Trimmer, J.S., Nerbonne, J.M., and Strauss, H.C. Distinct transient outward potassium current (I_to) phenotypes and distribution of fast-activating potassium channel -subunits in ferret left ventricular myocytes. Journal of General Physiology 113: 581-600 (1999).

Wang, Z., Feng, J., Shi, H., Pond, A., Nerbonne, J.M., and Nattel, S. Potential molecular basis of different physiological properties of the transient outward K⁺ current in rabbit and human hearts. Circulation Research 84: 551-561 (1999).

Petersen, K.R., and Nerbonne, J.M. Expression environment determines K⁺ current properties: Kv1 and Kv4 -subunit-induced K⁺ currents in mammalian cell lines and cardiac myocytes. Pflügers Archives European Journal of Physiology 437: 381-392 (1999).

Barry, D.M., Xu, H., Schuessler, R., and Nerbonne, J.M. Functional knockout of the transient outward current, long QT syndrome and cardiac remodeling in mice expressing a dominant negative Kv4 -subunit. Circulation Research 83: 560-567 (1998).

Malin, S.A., Guo, A.W.-X., Jafari, G., Goate, A.M., and Nerbonne, J.M. Presenilins upregulate functional K⁺ channel currents in mammalian cells. Neurobiology of Disease, 4: 398-409 (1998).

Boyle, W.A., Muralidharan, S., Maher, G.M., and Nerbonne, J.M. Vascular actions of caged-phenylephrine analogues depend on the structure and site of attachment of the photolabile group. Journal of Photochemistry and Photobiology 41: 233-244 (1997).

Takimoto, K., Li, D., Nerbonne, J.M., and Levitan, E.S. Distribution, splicing and glucorticoid-induced expression of cardiac _1C and _1D voltage-gated Ca²⁺ channel mRNAs. Journal of Molecular Cellular Cardiology 29: 3035-3042 (1997).

Locke, R.E., and Nerbonne, J.M. Role of voltage-gated K⁺ currents in mediating the regular-spiking phenotype of callosal-projecting rat visual cortical neurons. Journal of Neurophysiology 78: 2321-2335 (1997).

Locke, R.E., and Nerbonne, J.M. Three kinetically-distinct Ca²⁺ - independent depolarization-activated K⁺ currents in callosal-projecting rat visual cortical neurons. Journal of Neurophysiology 78: 2309-2320 (1997).

Van Wagoner, D.R., Pond, A.L., McCarthy, P.M., Trimmer, J.S., and Nerbonne, J.M. Outward K⁺ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation. Circulation Research 80: 772-781 (1997).

Xu, H., Dixon, J.E., Barry, D.M., Trimmer, J.S., Merlie, J.P., McKinnon, D., and Nerbonne, J.M. Developmental analysis reveals mismatches in the expression of K⁺ channel -subunits and voltage-gated K⁺ channel currents in rat ventricular myocytes. Journal of General Physiology 108: 405-420 (1996).

Tiaho, F., and Nerbonne, J.M. VIP and secretion augment voltage-gated L-type calcium channel currents in adult rat ventricular myocytes. Pflügers Archives, European Journal of Physiology 432: 821-830, (1996).

Albert, J.L., and Nerbonne, J.M. Calcium-independent depolarization-activated potassium currents in superior colliculus-projecting rat visual cortical neurons. Journal of Neurophysiology 73: 2163-2178 (1995).

Barry, D.M., Trimmer, J.S., Merlie, J.P., and Nerbonne, J.M. Differential expression of voltage-gated K+ channel subunits in the adult rat heart: Relationship to functional K⁺ channels? Circulation Research 77: 361-369 (1995).

Muralidharan, S., and Nerbonne, J.M. Photolabile "caged" adrenergic receptor agonists and related model compounds. Journal of Photochemistry and Photobiology 27: 123-127 (1995).

Bu, G., Maksymovitch, E.A., Nerbonne, J.M., and Schwartz, A.L. Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons. Journal of Biological Chemistry 269: 18521-18528 (1994).

Manchester, J., Kong, X., Nerbonne, J.M., Lowry, O.H., and Lawrence, J.C., Jr. Glucose transport in single ventricular myocytes: rate limiting steps in glucose uptake by control and insulin-stimulated cells. American Journal of Physiology 266: E326-E333 (1994).