Publications (including Invited Articles and Books)

Links indicate PDF attachments for online viewing

Since 1995

Schuller, D., Grant, G. A., and Banaszak, L. Crystal Structure Reveals the Allosteric Ligand Site in the Vmax -type Cooperative Emzyme: D-3-Phosphoglycerate Dehydrogenase. Nature Structural Biology 2, 69-76 (1995).

Strongin, A. Y., Collier, I., Bannikov, G., Marmer, B. I., Grant, G. A., and Goldberg, G. I. Mechanism of Cell Surface Activation of 72 kDa Type IV Collagenase: Isolation of the Activated Form of the Membrane Metalloprotease. J. Biol Chem. 270, 5331-5338 (1995).

Fiordalisi, J. J., James, P. L., Zhang, Y., and Grant, G. A. Facile Production of Native-like k-Bungarotoxin in Yeast: An Enhanced System for the Production of a Neuronal Acetylcholine Receptor Probe. Toxicon 34, 213-224 (1996).

Chiappinelli, V. A., Weaver, W. R., McLane, K. E., Conti-Fine, B. M., Fiordalisi, J. J., and Grant, G. A. (1996) The Binding Site for k-Neurotoxins on Neuronal Nicotinic Receptors Probed with Snake-Venom Derived and Recombinant Toxins. Toxicon 34, 1243-1256.

Grant, G. A., Schuller, D. J., and Banaszak, L. J. A Model for the Regulation of D-3-Phosphoglycerate Dehydrogenase, a Vmax-Type Allosteric Enzyme. Protein Science 5, 34-41 (1996).

De Jongh, K., Fernandez, J., Gambee, J. E., Grant, G. A., Stone, K. L., Merrill, B., and Rush, J. Design and Analysis of ABRF-95SEQ, a Recombinant Protein with Sequence Heterogeneity. In Techniques in Protein Chemistry VII (Marshak, D. R., ed.) Academic Press (1997), pp. 347-358.

Al-Rabiee, R., Lee, E. J., and Grant, G. A. The Mechanism of Velocity Modulated Regulation in D-3-Phosphoglycerate Dehydrogenase: Cross-linking Adjacent Regulatory Domains with Engineered Disulfides Mimics Effector Binding. J. Biol. Chem., 271, 13013-13017 (1996).

Fernandez, J., Admon, A., De Jongh, K., Grant, G., Henzel W., Lane, W. S., Stone, K. L., and Merrill, B. Evaluation of ABRF-96SEQ: A Sequence Assignment Exercise. In Techniques in Protein Chemistry VIII (Marshak, D. R., ed.) Academic Press (1997).

Al-Rabiee, R., Zhang, Y., and Grant, G. A. The Mechanism of Velocity Modulated Regulation in D-3-Phosphoglycerate Dehydrogenase: Site Directed Mutagenesis of Effector Binding Site Residues. J. Biol. Chem. 271, 23235-23238 (1996).

Gorman, S. Viseshakul, N., Cohen, B., Hardy, S., Grant, G. A., Yost, C. S., and Forsayeth J. R. (1997) A Recombinant Adenovirus that Directs Secretion of Biologically Active k-Bungarotoxin from Mammalian Cells. Molecular Brain Research 44, 143-146.

Grant, G. A., Al-Rabiee, R., Xu, X. L., and Zhang, Y. (1997) Critical Interactions at the Dimer Interface of k-Bungarotoxin. Biochemistry 36, 3353-3358.

Rozwarski, D. A., Grant, G. A., Barton, D. H. R., Jacobs, W. R. Jr., and Sacchettini, J. C. (1998) Modification of the NADH of the Isoniazid Target (InhA) from Mycobacterium tuberculosis. Science, 279, 98-102.

Grant, G. A., and Xu, X. L. (1998) Probing the Regulatory Domain Interface of D-3-Phosphoglycerate Dehydrogenase with Engineered Tryptophan Residues. J. Biol. Chem. 273, 22389-22394.

Grant, G. A., Luetje, C. W., Summers, R., and Xu, X. L. (1998) Differential Roles for Disulfide Bonds in the Structural Integrity and Biological Activity of k-Bungarotoxin, a Neuronal Nicotinic Acetylcholine Receptor Antagonist, Biochemistry 37, 12166-12171.

Grant, G. A., Kim, S. J., Xu, X. L., and Hu, Z. (1999) The Contribution of Adjacent Subunits to the Active Sites of D-3-Phosphoglycerate Dehydrogenase. J. Biol. Chem. 274, 5357-5361.

Grant, G. A., Xu, X. L., and Hu, Z. (1999) The Relationship Between Effector Binding and Inhibition of Activity in D-3-Phosphoglycerate Dehydrogenase. Protein Science 8, 2501-2505.

Grant, G. A., Xu, X. L., Hu, Z., and Purvis A. R. (1999) Phosphate Ion Partially Relieves the Cooperativity of Effector Binding in D-3-Phosphoglycerate Dehydrogenase without Altering The Cooperativity of Inhibition. Biochemistry 38, 16548-16552.

Grant, G. A., Xu, X. L., and Hu, Z. (2000) Removal of the Tryptophan 139 Side Chain in E. coli D-3-Phosphoglycerate Dehydrogenase Produces a Dimeric Enzyme Without Cooperative Effects. Arch. Biochem. Biophys 375, 171-174.

Grant, G. A., Xu, X. L., and Hu, Z. (2000) The Role of an Interdomain Gly-Gly Sequence at the Regulatory-Substrate Domain Interface in the Regulation of E. coli. D-3-Phosphoglycerate Dehydrogenase. Biochemistry 39, 7316-7319.

Grant, G. A., Hu, Z. and Xu, X. L. (2001) Specific Interactions at the Regulatory Domain-Substrate Binding Domain Interface Influence the Cooperativity of Inhibition and Effector Binding in E. coli. D-3-Phosphoglycerate Dehydrogenase. J. Biol. Chem. 276, 1078-1083.

Grant, G. A., Hu, Z. and Xu, X. L. (2001) Amino Acid Residue Mutations Uncouple Cooperative Effects in E. coli. D-3-Phosphoglycerate Dehydrogenase. J. Biol. Chem. 276, 17844-17850.

Bell, J. K., Pease, P. J., Bell, J. E., Grant, G. A., and Banaszak, L. J. (2002) Deregulation of D-3- Phosphoglycerate Dehydrogenase by Domain Removal. Eur. J. Biochem. 269, 4176-4184.

Grant, G. A., Hu, Z. and Xu, X. L. (2002) Cofactor Binding to E. coli D-3 Phosphoglycerate Dehydrogenase Induces Multiple Conformations Which Alter Effector Binding. J. Biol. Chem. 277, 39548-39553.

Grant, G. A., Hu, Z. and Xu, X. L. (2003) Hybrid Tetramers Reveal Elements of Cooperativity in E. coli D-3- Phosphoglycerate Dehydrogenase. J. Biol. Chem. 278, 18170-18176.

Ramanadham, S., Song, H., Hsu, F-F., Zhang, S., Crankshaw, M., Grant, G. A., Newgard, C. B., Bao, S., Ma, Z., and Turk, J. (2003) Pancreatic Islets and Insulinoma Cells Express a Novel Isoform of Group VIa Phospholipase A2 (iPLA2b) that participates in Glucose-Stimulated Insulin Secretion and is not Produced by Alternate Splicing of the iPLA2b Transcript. Biochemistry, 42, 13929-13940.

Grant, G. A., Xu, X. L., and Hu, Z. (2004) Quantitative relationships of site to site interaction in E. coli D-3-phosphoglycerate dehydrogenase revealed by asymmetric hybrid tetramers. J. Biol. Chem. 279, 13452-13460.

Bell, J. K., Grant, G. A., and Banaszak, L. J. (2004) Multi-conformational States in Phosphoglycerate Dehydrogenase. Biochemistry 43, 3450-3458.

Dey, S., Hu, Z., Xu, X. L., Sacchettini, J. C., and Grant, G. A. (2005) D-3-Phosphoglycerate Dehydrogenase from Mycobacterium Tuberculosis is a Link Between the E. coli and Mammalian Enzymes. J. Biol. Chem. 280, 14884-14891.

Dey, S., Grant, G. A., and Sacchettini, J. C. (2005) Crystal Structure of Mycobacterium tuberculosis D-3-Phosphoglycerate Dehydrogenase: Extreme Asymmetry in a Tetramer of Identical Subunits. J. Biol. Chem. 280, 14892-14899.

Thompson, J. R., Bell, J. K., Bratt, J., Grant, G. A., and Banaszak, L. J. (2005) Vmax Regulation Through Domain and Subunit Changes. The Active Form of Phosphoglycerate Dehydrogenase. Biochemistry 44, 5763-5773.

Grant, G. A., Hu, Z., and Xu, X. L. (2005) Identification of Amino Acid Residues Contributing to the Mechanism of Cooperativity in Escherichia coli D-3-Phosphoglycerate Dehydrogenase. Biochemistry 44, 16844-16852.

Dey, S., Hu, Z., Xu, X. L., Sacchettini, J. C., and Grant, G. A. (2007) The Effect of Hinge Mutations on Effector Binding and Domain Rotation in Escherichia coli D-3-Phosphoglycerate Dehydrogenase. J. Biol. Chem. (2007) 282, 18418.

Burton, R. L., Chen, S., Xu, X. L., and Grant G. A. (2007) A Novel Mechanism for Substrate Inhibition in Mycobacterium tuberculosis D-3-Phosphoglycerate Dehydrogenase. J. Biol. Chem. 282, 31493-31503.

^Top

Invited Articles

Grant, G.A., Evaluation of Synthetic Peptides. In Synthetic Peptides: A User's Guide (Grant, G.A., ed.) W.H. Freeman, New York, pp. 185-258 (1992).

Crankshaw, M. W., and Gregory A. Grant. Identification of Modified Amino Acids in Protein Sequence Analysis, Association of Biomolecular Resource Facilities, Bethesda, Maryland (1993).

Grant, G.A., Peptides, Synthetic. In Molecular Biology and Biotechnology: A Comprehensive Desk Reference (Meyers, R.A., ed.) pp. 654-658 VCH, Weinheim, (1995).

Grant, G.A., Peptides, Synthetic. In Encyclopedia of Molecular Biology: Fundamentals and Applications (Meyers, R.A., ed.) pp. 361-371 VCH, Weinheim, (1996).

Crankshaw, M. W. and Grant, G. A. Modification of Cysteine In Current Protocols in Protein Science, John Wiley and Sons, New York, pp. 15.1.1 - 15.1.18., (1996).

Grant, G. A., and Crankshaw, M. W. Identification of PTH-Amino Acids by High-Performance Liquid Chromatography, in Protein Sequencing Protocols, ( B. J. Smith, Ed.) Humana Press, pp. 197- 215, (1996).

Grant, G. A., Crankshaw, M. W., and Gorka, J. Edman Sequencing as a Tool for the Characterization of Synthetic Peptides. Meth. Enzymol. 289, 395-419 (1997).

Grant, G. A. Synthetic Peptides for the Production of Antibodies that Recognize Intact Proteins In Current Protocols in Protein Science, John Wiley and Sons, New York, pp. 18.3.1 - 18.3.17, (1998)

Grant, G. A. Structure, Function, and Biophysical Aspects of k-Neurotoxins, In Journal of Toxicology-Toxin Reviews 17, 239-260 (1998).

Grant, G. A., and Crankshaw, M. W. Identification of PTH-Amino Acids by High-Performance Liquid Chromatography, in Protein Sequencing Protocols, 2nd edition ( B. J. Smith, Ed.) Humana Press, pp. 247-268 (2002).

Grant, G. A. Synthetic Peptides for the Production of Antibodies that Recognize Intact Proteins In Current Protocols in Protein Science, John Wiley and Sons, New York, pp. 18.3.1 - 18.3.17, (revised 2002).

Grant, G. A. Synthetic Peptides for the Production of Antibodies that Recognize Intact Proteins In Current Protocols in Immunology, John Wiley and Sons, New York, pp. 9.2.1 - 9.2.18, (2002).

Grant, G. A. Methods for Analyzing Cooperativity in Phosphoglycerate Dehydrogenase. Meth. Enzymol. 380, 106-131, (2004).

Grant, G.A., Peptides, Synthetic. In Encyclopedia of Molecular Cell Biology and Molecular Medicine (Meyers, R.A., ed.) Vol. 3, 2nd Edition, pp. 239-260, VCH, Weinheim (2004).

Grant, G. A., Crankshaw, M. W., and Crankshaw, C. L. Enzyme Digestion Strategies for Sequence Analysis. Encyclopedia of Mass Spectrometry, Vol 2, Biological Applications Part A: Peptides and Proteins. (R. Caprioli and M. Gross, eds.) Elsevier (2005), pp. 151-157.

Grant, G. A. (2006) The ACT Domain: A Small Molecule Binding Domain and its Role as a Common Regulatory Element. J. Biol. Chem. 281, 33825-33829.

Grant, G.A., Design and Application of Synthetic Peptides In Proteins (Meyers, R.A., ed.) Vol. 1, pp. 431-452, VCH, Weinheim (2007).

^Top

Books

Synthetic Peptides: A User's Guide (Grant, G.A., ed.) W.H. Freeman, Inc., New York, (1992).

Synthetic Peptides: A User's Guide, Second Edition (Grant, G.A., ed.) Oxford University Press, New York (2002).

This page was last updated Tuesday, October 16, 2007